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Related Experiment Videos

The questionably dry eye

I A Mackie, D V Seal

    The British Journal of Ophthalmology
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Diagnosing dry eye disease can be challenging due to other conditions. This study links low tear lysozyme concentration to dry eye and suggests a modified Schirmer I test for better assessment.

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    Area of Science:

    • Ophthalmology
    • Clinical Diagnosis
    • Tear Film Analysis

    Background:

    • Dry eye diagnosis can be complicated by co-existing external eye conditions like papillary conjunctivitis.
    • Accurate assessment of dry eye requires correlating various diagnostic factors.

    Purpose of the Study:

    • To investigate reliable indicators for diagnosing dry eye disease when clinical presentation is ambiguous.
    • To evaluate the relationship between tear film particulate matter, lysozyme concentration, and tear flow.
    • To propose a modification to the Schirmer I test for improved dry eye detection.

    Main Methods:

    • Correlation analysis of factors assessed for ocular dryness.
    • Measurement of tear film particulate matter and tear lysozyme concentration.

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  • Evaluation of the Schirmer I test and a proposed modification.

    • Main Results:

    • Particulate matter in the unstained tear film correlates with low tear lysozyme concentration.
    • Low tear lysozyme concentration (ratio < 1.0) is associated with keratoconjunctivitis sicca.
    • The modified Schirmer I test can identify severe lysozyme depletion but is less reliable for moderate depletion; a 6 mm cutoff is suggested.

    Conclusions:

    • Tear lysozyme concentration is a key indicator in diagnosing dry eye, particularly when other conditions are present.
    • A modified Schirmer I test, with a lowest normal limit of 6 mm, aids in detecting severe cases of dry eye.
    • Further refinement may be needed for the test's reliability in cases of moderate lysozyme depletion.