Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clot retraction facilitates clot lysis

R C Carroll, J M Gerrard, J M Gilliam

    Blood
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Platelets significantly speed up blood clot breakdown (lysis) by causing clot retraction. This retraction mechanism is key to how platelets facilitate fibrinolysis, impacting deep vein thrombosis development.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Advanced crystallisation methods for small organic molecules.

    Chemical Society reviews·2023
    Same author

    Zinc inhibition of electron transfer: mechanism of beta receptor inhibition?

    Redox report : communications in free radical research·2016
    Same author

    Further Studies on the Effects of the Intracellular Histamine Antagonist DPPE on Platelet Function.

    Platelets·2010
    Same author

    NMDA receptors mediate calcium-dependent, bidirectional changes in dendritic PICK1 clustering.

    Molecular and cellular neurosciences·2006
    Same author

    SR-90107 (Sanofi-Synthélabo).

    IDrugs : the investigational drugs journal·2005
    Same author

    Synergistic outside-in regulation of platelet activation by GPIIb/IIIa ligand-induced conformation and oligomerization.

    Thrombosis research·2001

    Area of Science:

    • Hematology
    • Biochemistry

    Background:

    • Fibrinolysis, the breakdown of blood clots, is crucial for preventing thrombosis.
    • Platelets play a complex role in hemostasis and thrombosis, including clot formation and lysis.

    Purpose of the Study:

    • To investigate the mechanism by which platelets facilitate clot lysis.
    • To determine the specific contribution of platelet-induced clot retraction to fibrinolysis.

    Main Methods:

    • Utilized the dilute clot lysis assay to measure fibrinolysis rates.
    • Compared lysis of clots from platelet-rich plasma (PRP) versus platelet-poor plasma (PPP).
    • Manipulated clot retraction using centrifugation and cytochalasin B.

    Main Results:

    • Platelet-poor plasma clots exhibited significantly prolonged lysis compared to platelet-rich plasma clots.

    Related Experiment Videos

  • Centrifugal compaction of platelet-poor plasma clots accelerated lysis, mimicking retraction effects.
  • Inhibition of clot retraction in platelet-rich plasma clots with cytochalasin B prolonged lysis.

    • Conclusions:

    • Platelet-induced clot retraction is a major mechanism facilitating clot lysis.
    • Platelets enhance fibrinolysis primarily through their ability to induce clot retraction.