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Work induced myocardial glycogen resynthesis

P B Taylor, D A Hunt

    Canadian Journal of Applied Sport Sciences. Journal Canadien Des Sciences Appliquees Au Sport
    |December 1, 1980
    PubMed
    Summary
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    Myocardial glycogen resynthesis in isolated perfused hearts depends on workload intensity and substrate availability. Severely depleted hearts show faster glycogen replenishment rates with increased glucose or pyruvate.

    Area of Science:

    • Cardiovascular Physiology
    • Metabolic Biochemistry

    Background:

    • Myocardial glycogen is a critical energy substrate for cardiac function.
    • Understanding glycogen repletion mechanisms is vital for managing cardiac energy metabolism during stress.

    Purpose of the Study:

    • To investigate work-induced myocardial glycogen repletion in an isolated perfused heart model.
    • To determine the influence of workload, substrate concentration, and alternative carbon sources on glycogen resynthesis.

    Main Methods:

    • Isolated perfused rat heart preparation subjected to varying workloads (low and high).
    • Substrate-free buffer perfusion followed by a recovery phase with glucose or glucose and pyruvate.
    • Measurement of myocardial glycogen levels before and after perfusion protocols.

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    Main Results:

    • High workload significantly depleted myocardial glycogen (61%) compared to low workload (29%).
    • Glycogen resynthesis rates were higher in more severely depleted hearts.
    • Increased glucose concentrations (5.5 mM to 22 mM) enhanced glycogen repletion.
    • Supplementation with sodium pyruvate alongside glucose further boosted glycogen resynthesis.

    Conclusions:

    • The isolated perfused heart is a suitable model for studying work-induced glycogen repletion.
    • Glycogen repletion is influenced by preceding workload, glucose concentration, and the presence of pyruvate.
    • Metabolic flexibility in substrate utilization impacts cardiac energy recovery.