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Related Experiment Videos

Pseudohypertension in sinoaortic-denervated rats

R A Norman, T G Coleman, A C Dent

    Clinical Science (London, England : 1979)
    |December 1, 1980
    PubMed
    Summary

    Sinoaortic-denervated rats appear hypertensive when pressure is measured during restraint. However, continuous 24-hour monitoring reveals these rats are actually normotensive, indicating restraint causes a false hypertension reading.

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    Area of Science:

    • Physiology
    • Cardiovascular Research

    Background:

    • The sinoaortic denervation (SAD) procedure removes baroreceptors, which are crucial for regulating blood pressure.
    • Understanding the impact of SAD on blood pressure regulation is essential for cardiovascular research.

    Purpose of the Study:

    • To investigate the effect of restraint on blood pressure measurements in sinoaortic-denervated rats.
    • To compare continuous 24-hour blood pressure monitoring with short-term measurements during restraint in SAD rats.

    Main Methods:

    • Continuous 24-hour mean arterial pressure (MAP) monitoring via computerized data collection.
    • Direct and indirect blood pressure measurements during restraint in metabolic cages.
    • Comparison of MAP between control and SAD rats.

    Main Results:

    • Restraint measurements indicated hypertension in SAD rats (MAP 145 mmHg vs. 119 mmHg in controls).
    • Continuous 24-hour monitoring showed normotension in SAD rats (MAP 119 mmHg vs. 119 mmHg in controls).
    • Tail-cuff pressures were significantly higher in SAD rats during restraint.

    Conclusions:

    • Blood pressure measurements made during restraint can falsely indicate hypertension in sinoaortic-denervated rats.
    • Continuous monitoring is crucial for accurate assessment of blood pressure in SAD models.
    • Restraint stress elevates arterial pressure in SAD rats, mimicking hypertension.

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