Changes of serum protein and immunoglobulin in toxemia of pregnancy

The immune mechanism theoretically may play an important role in toxemia of pregnancy. Serum proteins, immunoglobulins and C3 were measured in 20 women with normal pregnancy and in 10 women with toxemia of pregnancy. Compared with the normal pregnancy, the toxemia group exhibited decreased albumin and IgG, and significant increases in alpha 1 globulin and IgE. The immunological implication of these changes deserves further investigation.