Stimulating effects of lisuride on masculine sexual behavior of rats

Treatment of adult male rats with lisuride, an ergot derivative, resulted in selective changes in the masculine mating pattern. A dose-dependent decrease was found in the number of intromissions preceding ejaculation and in the ejaculatory latency. No other components of the mating pattern showed any significant alteration. Further, castrated sexually inexperienced rats treated with lisuride displayed a dose-dependent increase in complete heterosexual behavior.