[Effect of GABA-ergic substances on the conditioned avoidance reaction in rats]

The effect of GABA-ergic substances on the production and latent period of the conditioned reflex of avoidance in rats has been studied. The inhibitor of GABA-transaminase n-dipropylacetate (depakin) deteriorates the reflex production. Fenibut and amino oxyacetic acid significantly prolong the latent period of the produced conditioned reflex of avoidance. The effect of amino oxyacetic acid on the conditioned reflex is abolished by bicuculline and is likely to be related to the increased brain GABA content.