[Effect of a physical load on the toxicological characteristics of sodium oxybutyrate]

Toxicity of sodium hydroxybutyrate administered for a long time was studied in freely moving animals and in those exposed to intense exercise (daily swimming for 30 min). Hematological, biochemical and morphological analyses demonstrated the drug to be little toxic. Intense exercise did not entail the increased toxicity of sodium hydroxybutyrate. On the contrary, the biochemical parameters (the content of creatinine, protein and protein fractions) altered by exercise returned to normal as a result of a prolonged administration of the drug.