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[Compounds with potential antitumor activity. VI. Esters of 6-substituted 5-hydroxymethylimidazo(2,1-b)thiazoles]
Abstract:
6-Substituted 5-hydroxymethylimidazo[2.1-b]thiazoles and 2,3-dihydro-5-hydroxymethylimidazo[2,1-b]thiazoles (VII - XII) were prepared by reducing the corresponding aldehydes (I - VI) with NaBH4. Among the acetic (VII a - XII a), methylcarbamic (VII b - XII b) and ethylcarbamic esters (VII c - XII c), compound (VII a) was active in a preliminary P388 leukemia test.