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Updated: Aug 11, 2026

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
Published on: July 4, 2007
The auto-induction of carbamazepine during long-term therapy
Abstract:
Healthy male volunteers during regular therapy of carbamazepine had a statistically significant decrease in their plasma drug levels during a period of 28 days. The same phenomenon was also registered in epileptic patients in the course of their long-term monotherapy with carbamazepine. Neither in volunteers nor in epileptics did any statistically significant change in the plasma levels of carbamazepine-10,11-epoxide occur. Wide fluctuations between the fasting and peak plasma level of carbamazepine were found in epileptics. Neither the fasting nor peak plasma levels of the drug correlated in a statistically significant degree with the daily dose of carbamazepine.
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