Changes in renal hemodynamics in experimental hydronephrosis

We measured mean renal blood flow and intrarenal blood flow distribution in 40 dogs using the xenon-133 washout technique 3 and 7 hr; 1, 2, and 3 weeks; and 4 and 6 months after unilateral complete ligation of the ureter. Mean renal blood flow rapidly decreased before renal atrophy. The data show an early redistribution of intrarenal hemodynamics with a predominant decrease in compartment I flow. These data are discussed with respect to possible ischemic atrophy especially in the renal cortex.