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Necrotising enterocolitis and neuraminidase-producing bacteria
Helvetica Paediatrica Acta
|May 1, 1980
Summary
Necrotising enterocolitis (NEC) in newborns can expose Thomsen-cryptantigen (T-antigen) on red blood cells. This may cause transfusion reactions, necessitating T-antigen testing and specific blood products.
Area of Science:
- Neonatal Medicine
- Immunology
- Transfusion Medicine
Background:
- Necrotising enterocolitis (NEC) is a severe condition in newborns.
- Exposure of red blood cell surface antigens can occur in disease states.
Purpose of the Study:
- To investigate the presence of Thomsen-cryptantigen (T-antigen) on red blood cells in newborns with NEC.
- To assess the clinical significance and transfusion implications of T-antigen exposure in NEC.
Main Methods:
- Demonstration of T-antigen on red blood cells in newborns with NEC.
- Isolation of potential causative microorganisms (neuraminidase-producing clostridia).
- Correlation of serological titres with clinical course.
Main Results:
- T-antigen exposure was observed in 9 out of 26 newborns with NEC.
- Exposure is likely due to bacterial neuraminidase activity.
- Serological titres correlated with the clinical course of NEC.
- Neuraminidase-producing clostridia were isolated from two patients.
Conclusions:
- T-antigen exposure in NEC poses a potential blood transfusion hazard due to reaction with naturally occurring anti-T-agglutinins.
- Routine T-antigen testing and use of specific blood products (packed or washed red blood cells) are recommended for T-antigen-positive patients to prevent transfusion complications.