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Inner ear disease characterized by rolling in C3H mice
Journal of the American Veterinary Medical Association
|November 1, 1980
Summary
A neurologic disease causing rolling in C3H mice was linked to Pseudomonas aeruginosa. Acidifying drinking water significantly reduced disease incidence, suggesting a method for prevention.
Area of Science:
- Neurology
- Microbiology
- Veterinary Medicine
Background:
- A neurologic disease characterized by rolling behavior was observed in a specific mouse strain (C3H).
- The condition involved severe inflammation and infection of the ear and meninges.
Purpose of the Study:
- To identify the causative agent of the neurologic disease in C3H mice.
- To investigate potential contributing factors and preventive measures for the observed disease.
Main Methods:
- Isolation and identification of microorganisms from affected mice.
- Pathological examination of affected tissues (middle ear, inner ear, meninges).
- Intervention study involving acidification of drinking water.
Main Results:
- Pseudomonas aeruginosa was consistently isolated from the middle ear, inner ear, and meninges of affected mice.
- The primary pathological finding was aggressive, purulent otitis media with extension to adjacent structures.
- Acidification of drinking water led to a near-complete elimination of the disease.
Conclusions:
- Pseudomonas aeruginosa is implicated as the causative agent of this neurologic disease in C3H mice.
- Environmental modification, specifically water acidification, is a highly effective strategy for disease prevention.