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Inner ear disease characterized by rolling in C3H mice
Abstract:
A neurologic disease characterized by rolling developed in C3H mice. Pseudomonas aeruginosa was isolated from the middle and internal ears or meninges of affected mice. The principal pathologic finding was aggressive, primary, purulent otitis media, with extension to the inner ear, acoustic nerve, and meninges. Stresses that may have contributed to induction of the disease were not delineated; however, acidification of the drinking water resulted in near elimination of the disease.
Insights
A neurologic disease causing rolling in C3H mice was linked to Pseudomonas aeruginosa. Acidifying drinking water significantly reduced disease incidence, suggesting a method for prevention.
Area of Science:
- Neurology
- Microbiology
- Veterinary Medicine
Background:
- A neurologic disease characterized by rolling behavior was observed in a specific mouse strain (C3H).
- The condition involved severe inflammation and infection of the ear and meninges.
Purpose of the Study:
- To identify the causative agent of the neurologic disease in C3H mice.
- To investigate potential contributing factors and preventive measures for the observed disease.
Main Methods:
- Isolation and identification of microorganisms from affected mice.
- Pathological examination of affected tissues (middle ear, inner ear, meninges).
- Intervention study involving acidification of drinking water.
Main Results:
- Pseudomonas aeruginosa was consistently isolated from the middle ear, inner ear, and meninges of affected mice.
- The primary pathological finding was aggressive, purulent otitis media with extension to adjacent structures.
- Acidification of drinking water led to a near-complete elimination of the disease.
Conclusions:
- Pseudomonas aeruginosa is implicated as the causative agent of this neurologic disease in C3H mice.
- Environmental modification, specifically water acidification, is a highly effective strategy for disease prevention.