Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Protein-losing enteropathy in six macaques

R F Rodger, R T Bronson, K W McIntyre

    Journal of the American Veterinary Medical Association
    |November 1, 1980
    PubMed
    Summary

    Radioactive labeled chromic chloride identified protein-losing enteropathy in macaques with weight loss. Diseased macaques excreted significantly more of the radioactive tracer than healthy ones.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Strain- and Diet-Related Lesion Variability in Aging DBA/2, C57BL/6, and DBA/2xC57BL/6 F1 Mice.

    Veterinary pathology·2015
    Same author

    Selective Inhibition of SIRT2 Improves Outcomes in a Lethal Septic Model.

    Current molecular medicine·2015
    Same author

    Inactivation of the retinoblastoma gene yields a mouse model of malignant colorectal cancer.

    Oncogene·2015
    Same author

    MUC1-C activates the TAK1 inflammatory pathway in colon cancer.

    Oncogene·2015
    Same author

    Phenotypic characterization of the KK/HlJ inbred mouse strain.

    Veterinary pathology·2013
    Same author

    Studies of aging in ames dwarf mice: Effects of caloric restriction.

    Journal of the American Aging Association·2013

    Area of Science:

    • Veterinary Medicine
    • Gastroenterology
    • Primate Research

    Background:

    • Protein-losing enteropathy (PLE) is a condition characterized by excessive loss of plasma proteins into the gastrointestinal tract.
    • Hypoalbuminemia and progressive weight loss are common clinical signs associated with PLE.
    • Identifying the underlying causes and diagnostic methods for PLE in non-human primates is crucial for their health management.

    Purpose of the Study:

    • To document protein-losing enteropathy in macaques using radioactive labeled chromic chloride.
    • To quantify protein loss in macaques with clinical signs of PLE.
    • To correlate gastrointestinal lesions with the diagnosis of PLE.

    Main Methods:

    • Intravenous administration of radioactive labeled chromic chloride, which binds to plasma proteins.
    • Measurement of fecal excretion of the radioactive label over a 4-day period.
    • Histopathological examination of small intestinal tissues to identify characteristic lesions.

    Main Results:

    • Six macaques diagnosed with protein-losing enteropathy exhibited progressive weight loss and hypoalbuminemia.
    • Diseased macaques lost significantly higher percentages of the radioactive label in feces (1.0%–14.2%) compared to healthy controls (0.5% ± 0.1%).
    • Associated small intestinal lesions included lymphangiectasia, amyloidosis, mast cell proliferation, and goblet cell hyperplasia.

    Conclusions:

    • Radioactive labeled chromic chloride is an effective diagnostic tool for documenting protein-losing enteropathy in macaques.
    • Specific histopathological findings in the small intestine are associated with protein-losing enteropathy in this primate model.
    • This study highlights the utility of radionuclide tracers in diagnosing gastrointestinal protein loss in veterinary medicine.

    Related Experiment Videos