Dermatoimmunopathology of scabies

Direct immunofluorescence of scabies lesions revealed IgM, IgA, C3, and fibrin in the cornified layer of the epidermis, dermoepidermal junction, and papillary dermal vessels. The granular deposits of IgM and IgG in the dermoepidermal junction had a pattern similar to that found in lupus erythematosus. These findings support a humoral immune response secondary to scabetic infestation.