Anaphylaxis after sesame seed ingestion

Area of Science:

• Immunology
• Allergology
• Food Science

Background:

• Systemic anaphylaxis, angioedema, and urticaria can be triggered by sesame seed and sesame oil ingestion.
• Identifying specific allergens is crucial for managing sesame allergy.

Purpose of the Study:

• To investigate the presence of specific IgE antibodies against sesame seed extract in patients with confirmed sesame allergy.
• To characterize the molecular weight of the primary allergens responsible for sesame-induced allergic reactions.

Main Methods:

• Radioallergosorbent test (RAST) was employed to detect anti-sesame seed extract IgE antibodies in four patients.
• RAST inhibition assays were performed following density-gradient ultracentrifugation of sesame seed extract.

Main Results:

• Three out of the four studied patients tested positive for anti-sesame seed IgE antibodies via RAST.
• RAST inhibition indicated that the most potent sesame allergens possess molecular weights ranging from 8,000 to 62,000 daltons.

Conclusions:

• Specific IgE antibodies to sesame seed extract are prevalent in patients experiencing systemic allergic reactions to sesame.
• The identified molecular weight range provides insights into the nature of sesame allergens, aiding in diagnosis and management.