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Related Experiment Videos

Systemic tolerance and secretory immunity after oral immunization

S J Challacombe, T B Tomasi

    The Journal of Experimental Medicine
    |December 1, 1980
    PubMed
    Summary

    Oral immunization can induce both salivary antibodies and systemic immune suppression. This study in mice demonstrates that intragastric antigen administration concurrently produces secretory IgA antibodies and a diminished immune response.

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    Area of Science:

    • Immunology
    • Oral immunology
    • Vaccinology

    Background:

    • Oral administration of antigens can lead to immune tolerance or antibody production.
    • Previous studies suggest oral immunization may induce systemic immune suppression or secretory antibodies, but not concurrently.

    Purpose of the Study:

    • To investigate whether oral immunization can simultaneously induce systemic immune suppression and secretory antibody production.
    • To determine the dose-dependency and duration of these immune responses.
    • To identify the class of salivary antibodies produced.

    Main Methods:

    • CBA/J mice were intragastrically immunized with ovalbumin (OVA) or Streptococcus mutans.
    • Animals were systemically challenged with antigen in complete adjuvant.
    • Serum, saliva, and draining lymph nodes were analyzed for antibody production and proliferative responses.

    Main Results:

    • Intragastric administration of OVA or S. mutans suppressed the lymph node proliferative response.
    • Higher doses of OVA or S. mutans induced detectable salivary antibodies, identified as IgA.
    • Serum antibodies were not detected, and suppression persisted for weeks.
    • Transfer of mesenteric lymph node cells induced suppression in recipients.

    Conclusions:

    • Intragastric antigen administration can concurrently induce salivary IgA antibodies and systemic immune suppression in mice.
    • These findings suggest a dual role for oral immunization in modulating immune responses.
    • The study highlights the potential for developing oral vaccines that elicit both local and systemic immunity.

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