Glycine in the central nervous system in experimental allergic encephalomyelitis

The content of glycine, a possibly inhibitory neurotransmitter was studied in central nervous system of guinea pigs with experimental allergic encephalomyelitis (EAE). The glycine level was increased in spinal cord, but not in the brain of animals with EAE. The greatest increase in glycine concentration was in lumbosacral cord, and at the time of appearance of clinical signs of diseases. The results are discussed in terms of possible connection between the changes of glycine concentration and clinical signs of EAE.