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Solvent-induced occupational myopathy

L M Pedersen, E Nygaard, O S Nielsen

    Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association
    |September 1, 1980
    PubMed
    Summary
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    Occupational solvent exposure elevates serum creatine kinase (CK) and alters muscle enzyme activity, indicating skeletal muscle involvement in solvent intoxication and suggesting CK as a myopathy indicator.

    Area of Science:

    • Occupational Medicine
    • Toxicology
    • Biochemistry

    Background:

    • Occupational exposure to solvents is a significant health concern.
    • Previous studies have not fully elucidated the impact of solvents on skeletal muscle.

    Purpose of the Study:

    • To investigate the effects of occupational solvent intoxication on skeletal muscle.
    • To identify potential biomarkers for solvent-induced myopathy.

    Main Methods:

    • Serum creatine kinase (CK) levels were measured in solvent-exposed patients and controls.
    • Muscle biopsies were analyzed for lactate dehydrogenase (LDH) and succinate dehydrogenase (SDH) activity.
    • Serum CK isoenzyme analysis was performed.

    Main Results:

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    • Significantly higher serum CK levels were observed in solvent-intoxicated patients.
    • Elevated muscle LDH and reduced muscle SDH activity were found in patients.
    • Serum CK elevation was attributed to the CKM isoenzyme fraction.
    • No histological abnormalities were detected via light microscopy.

    Conclusions:

    • Skeletal muscles are implicated as target organs in solvent intoxication.
    • Serum CK analysis, specifically the CKM fraction, can serve as a valuable indicator of solvent-induced myopathy.