Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Novel potential anticancer agents derived from benzimidazole

E S Ibrahim, A M Omar, M A Khalil

    Journal of Pharmaceutical Sciences
    |November 1, 1980
    PubMed
    Summary

    Researchers synthesized novel benzimidazole derivatives to test for anticancer properties. Unfortunately, these compounds, including alkylating agents and thiosemicarbazides, showed no significant antileukemic activity in preliminary tests.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Bioengineered nanocellulose-Schiff base sensor for selective fluorometric detection of Cd<sup>2+</sup> ions in aqueous media.

    International journal of biological macromolecules·2025
    Same author

    Novel amino-functionalized MOF-based sensor for zinc ion detection in water and blood serum samples.

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2024
    Same author

    An effective procedure used metal-organic framework for determination of cadmium ions in real tap water and human blood plasma samples.

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2024
    Same author

    Impact of the COVID-19 pandemic on hospitalizations for acute coronary syndromes: a multinational study.

    QJM : monthly journal of the Association of Physicians·2021
    Same author

    Structural modification of azolylacryloyl derivatives yields a novel class of covalent modifiers of hemoglobin as potential antisickling agents.

    MedChemComm·2020
    Same author

    Fungal deterioration of limestone false-door monument.

    Heliyon·2019

    Area of Science:

    • Medicinal Chemistry
    • Pharmacology
    • Organic Synthesis

    Background:

    • Benzimidazole derivatives are a recognized scaffold in drug discovery, often exhibiting diverse biological activities.
    • Structural modifications of existing drugs are a common strategy to develop novel therapeutic agents with improved efficacy or reduced toxicity.
    • Anticancer drug development requires continuous exploration of new chemical entities to overcome resistance and improve treatment outcomes.

    Purpose of the Study:

    • To synthesize and characterize two novel series of benzimidazole derivatives.
    • To evaluate the potential anticancer activity of these novel compounds.
    • To specifically assess antileukemic activity against P-388 lymphocytic leukemia.

    Main Methods:

    • Synthesis of two distinct series of benzimidazole derivatives: alkylating agents and 4-substituted-1-thioacetyl-3-thiosemicarbazides.

    Related Experiment Videos

  • In vitro evaluation of antileukemic activity using the P-388 lymphocytic leukemia cell line.
  • Assessment of cytotoxicity and efficacy of representative synthesized compounds.

    • Main Results:

    • Successful synthesis of novel benzimidazole derivatives belonging to two distinct chemical classes.
    • Preliminary screening revealed no significant antileukemic effects for the tested compounds against P-388 lymphocytic leukemia.
    • The evaluated benzimidazole derivatives did not demonstrate promising anticancer activity in this specific leukemia model.

    Conclusions:

    • The synthesized benzimidazole derivatives, including alkylating agents and thiosemicarbazides, did not exhibit significant antileukemic activity.
    • Further structural modifications or alternative biological targets may be necessary to develop effective anticancer agents based on this scaffold.
    • This study highlights the importance of rigorous screening in identifying promising anticancer drug candidates.