Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Flow through brushborders and similar protuberant wall structures

D Basmadjian, D S Dykes, A D Baines

    The Journal of Membrane Biology
    |October 31, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    O(2) affinity of cross-linked hemoglobins modifies O(2) metabolism in proximal tubules.

    Journal of applied physiology (Bethesda, Md. : 1985)·2003
    Same author

    Production of cysteinyl-dopamine during intravenous dopamine therapy.

    Kidney international·2001
    Same author

    Does dopamine use several signal pathways to inhibit Na-Pi transport in OK cells?

    Journal of the American Society of Nephrology : JASN·1998
    Same author

    Effect of modifying O2 diffusivity and delivery on glomerular and tubular function in hypoxic perfused kidney.

    The American journal of physiology·1998
    Same author

    Immunodetection of a type III sodium-dependent phosphate cotransporter in tissues and OK cells.

    Biochimica et biophysica acta·1998
    Same author

    Coagulation on biomaterials in flowing blood: some theoretical considerations.

    Biomaterials·1998
    Same journal

    In vitro Reconstitution of Syncytin-2 and MFSD2A Reveals their Functional Tethering in Membrane Fusion Initiation.

    The Journal of membrane biology·2026
    Same journal

    Structural Basis of SERCA Inhibition by Derivatives of di-tert-butylhydroquinone Revealed by X-ray Crystallography.

    The Journal of membrane biology·2026
    Same journal

    Fungal Extracellular Vesicles are Recoverable Across Variable Ultracentrifugation Speeds but Display Species-specific Profiles of Sedimentation.

    The Journal of membrane biology·2026
    Same journal

    Polyproline Modulates Membrane Translocation of Arginine-Rich Cell-Penetrating Peptides: Insights from Molecular Dynamics Simulations.

    The Journal of membrane biology·2026
    Same journal

    Peculiarities of Phosphatidylserine Externalization by Nano- and Microsecond Electric Pulses.

    The Journal of membrane biology·2026
    Same journal

    Protonation of Key Acidic Residues Reveals Binding Features of PCABs to Gastric H, K-ATPase.

    The Journal of membrane biology·2026
    See all related articles

    Fluid dynamics in kidney proximal tubules were studied using synthetic brush borders. Flow rates within these structures are minimal and primarily driven by diffusion, unlikely to impact radial gradients or transmural flux.

    Area of Science:

    • Fluid dynamics
    • Renal physiology
    • Biomimetic microfluidics

    Background:

    • Kidney proximal tubules feature complex internal structures called brush borders.
    • Understanding fluid dynamics within these microstructures is crucial for renal function.
    • Previous models often simplified brush border geometry and flow dynamics.

    Purpose of the Study:

    • To experimentally and theoretically investigate longitudinal flow through channels with protuberant wall structures, specifically synthetic brush borders.
    • To quantify the fractional flow rates within brush borders relative to the core flow.
    • To extrapolate findings to the physiological conditions of kidney proximal tubules.

    Main Methods:

    • Experiments utilized scaled tubes with synthetic internal brush borders mimicking kidney proximal tubule geometry.

    Related Experiment Videos

  • Dye trace transit times measured central core and total flow rates to deduce fractional flow rates.
  • Theoretical analysis employed the Kozeny-Carman equation for flow through parallel cylinder arrays.

    • Main Results:

    • Brush border to core flow ratios (QB/QC) were independent of Reynolds number (Re = 0.01 - 0.2).
    • Experimental results showed good agreement with theoretical predictions based on the Kozeny-Carman equation.
    • Extrapolation to kidney proximal tubules suggests brush border flow rates are 0.003% - 0.09% of total flow.

    Conclusions:

    • Flow within brush border structures is minimal and predominantly governed by diffusion.
    • Axial transport in brush borders is unlikely to significantly influence radial gradients or transmural flux.
    • The Kozeny-Carman model provides a basis for predicting flow in complex microchannel geometries, adaptable to turbulent conditions.