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Concentration of antibiotics in simple renal cysts
Abstract:
Patients with infected renal cysts are known to respond poorly to antibiotic therapy. We evaluated the serum, cyst fluid and urine levels of 3 antibiotics in 4 patients with simple renal cysts. Despite excellent urine and serum concentrations gentamicin was detected in the cyst of only 1 of the 3 patients studied. Neither sulfamethoxazole nor trimethoprim was detected in the cyst of 1 patient despite adequate plasma levels. These data help explain the poor medical response of such patients and support the concept of early surgical intervention.
Insights
Antibiotic penetration into infected renal cysts is poor, even with high serum levels. This explains why patients with infected renal cysts often do not respond well to antibiotic treatment, supporting early surgery.
Area of Science:
- Nephrology
- Infectious Diseases
- Pharmacology
Background:
- Infected renal cysts show poor response to antibiotic therapy.
- Understanding antibiotic penetration is crucial for treatment efficacy.
Purpose of the Study:
- To evaluate serum, cyst fluid, and urine levels of three antibiotics in patients with infected simple renal cysts.
- To elucidate the reasons behind the poor response to antibiotic treatment in such cases.
Main Methods:
- Analysis of antibiotic concentrations (gentamicin, sulfamethoxazole, trimethoprim) in serum, cyst fluid, and urine.
- Study involved four patients with simple renal cysts.
Main Results:
- Gentamicin was detected in cyst fluid in only one of three patients, despite adequate serum and urine levels.
- Sulfamethoxazole and trimethoprim were not detected in cyst fluid in one patient, despite adequate plasma levels.
Conclusions:
- Poor antibiotic penetration into renal cysts explains treatment failures.
- Findings support the consideration of early surgical intervention for infected renal cysts.