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Updated: Sep 27, 2026

A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model
Published on: October 14, 2016
Rosette-formation with mouse red blood cells in chronic lymphocytic leukemia and leukemic non-Hodgkin's lymphomas
Peripheral blood lymphocytes from 30 patients with chronic lymphocytic leukemia (CLL) and 18 patients with malignant non-Hodgkin's lymphomas in leukemic phase were studied for rosette-formation with neuraminidase-treated mouse erythrocytes. The proportion of rosette-forming cells in CLL was significantly higher (p < 0.001) than in 12 cases of lymphoplasmacytoid malignant lymphoma (LPL). Our results suggest that this test may be a helpful method in the differentiation of CLL from leukemic LPL, which usually can not be distinguished by morphological criteria alone.
Peripheral blood lymphocytes from 30 patients with chronic lymphocytic leukemia (CLL) and 18 patients with malignant non-Hodgkin's lymphomas in leukemic phase were studied for rosette-formation with neuraminidase-treated mouse erythrocytes. The proportion of rosette-forming cells in CLL was significantly higher (p < 0.001) than in 12 cases of lymphoplasmacytoid malignant lymphoma (LPL). Our results suggest that this test may be a helpful method in the differentiation of CLL from leukemic LPL, which usually can not be distinguished by morphological criteria alone.
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