Effect of a controlled exercise program on serum lipoprotein levels in women on oral contraceptives

The effects of a 10-wk individualized bicycle ergometer interval training program were investigated in a group of 13 sedentary women on a specific oral contraceptive (50 micrograms mestranol, 1 mg norethisterone) to determine if, like men on physical training, their high-density lipoprotein cholesterol levels would increase. Six additional women on the oral contraceptive served as a nonexercising control group. All subjects were between 18 and 30 yr and were nonsmokers. Diet and alcohol intake were stable throughout the study period, and were monitored throughout. The interval training program was three times per week, 30-min exercise per session, at 70% maximum heart rate reserve (resting heart rate + 0.7 x [maximum heart rate-resting heart rate]). Training produced increases (p < 0.05) in maximum oxygen uptake. Body weight was unchanged. However, unlike similar training programs with males, there were no significant changes in plasma high-density lipoprotein cholesterol or triglycerides. In women receiving estrogen progestin oral contraceptives, consistent exercise programs may fail to elevate high density lipoprotein cholesterol levels, consistent with an interaction of sex hormone-exercise effects and/or with the less marked effect of exercise on high-density lipoprotein cholesterol in women.