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Related Experiment Videos

Distributed digestion

W A Hemmings

    Medical Hypotheses
    |November 1, 1980
    PubMed
    Summary

    The classical theory of digestion, where all dietary protein breaks into amino acids before absorption, is challenged. New evidence suggests larger proteins are absorbed and utilized by tissues, potentially impacting cell function.

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    Proceedings of the Royal Society of London. Series B, Biological sciences·1978

    Area of Science:

    • Biochemistry
    • Physiology
    • Molecular Biology

    Background:

    • The traditional view of protein digestion posits complete breakdown to amino acids prior to absorption.
    • This model has long been the accepted paradigm in nutritional science and physiology.

    Purpose of the Study:

    • To challenge the classical theory of protein digestion and absorption.
    • To present evidence for the absorption of intact or high molecular mass dietary proteins.

    Main Methods:

    • Review of existing scientific literature and evidence.
    • Analysis of studies examining protein absorption and transport mechanisms.

    Main Results:

    • Evidence indicates that a significant portion of dietary protein is absorbed as high molecular mass proteins.
    • These proteins rapidly enter the bloodstream and are distributed to various body tissues.
    • Breakdown occurs within tissues via polypeptide intermediates, not solely in the digestive tract.

    Conclusions:

    • The classical theory of digestion, requiring complete amino acid breakdown before absorption, should be reconsidered.
    • Absorbed high molecular mass proteins and their polypeptide intermediates may play active roles in cellular functions and pharmacology.

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