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Related Experiment Videos

Predictive value and efficiency of laboratory testing

R S Galen

    Pediatric Clinics of North America
    |November 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Current reference values for medical tests fail to identify disease. New "referent values" are needed, derived from studying both healthy individuals and diverse patient groups to improve diagnostic accuracy.

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    Area of Science:

    • Clinical Chemistry
    • Diagnostic Medicine
    • Biostatistics

    Background:

    • Abundant literature exists on establishing reference values and intervals in healthy populations.
    • Current statistical methods for reference intervals do not provide meaningful clinical insights into disease states.
    • The concepts of 'normal values' and 'reference values' have proven inadequate for medical practice.

    Purpose of the Study:

    • To highlight the limitations of current reference values in diagnosing disease.
    • To propose a new approach for establishing "referent values" for improved diagnostic utility.
    • To emphasize the necessity of studying diverse patient populations for meaningful test interpretation.

    Main Methods:

    • Critically evaluating the existing methodologies for determining reference values.

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  • Analyzing the shortcomings of statistically derived reference intervals in identifying disease.
  • Proposing the study of laboratory test constituents across healthy individuals and various disease states.

    • Main Results:

    • Reference intervals derived solely from healthy individuals do not indicate disease.
    • Current reference values offer limited diagnostic value for clinical decision-making.
    • A significant gap exists in studies that include diverse patient cohorts for laboratory test evaluation.

    Conclusions:

    • "Normal" or "healthy" reference values are insufficient for medical diagnosis.
    • A shift towards "referent values" derived from comprehensive patient studies is essential.
    • Future research must incorporate diseased and non-diseased patient groups to make laboratory tests diagnostically meaningful.