Neuronal links in the CNS: focus on dopaminergic and serotonergic regulation of striatal cholinergic neurons

The paper reviews the previous data of the authors on the links between dopamine and acetylcholine and serotonin and acetylcholine systems in the striatum. The results of studies in which the effects of alteration of dopaminergic and serotonergic transmission on striatal acetylcholine level were assessed, indicate the presence of two independent striatal cholinergic neuron populations, one of which is under inhibitory control of serotonergic, and another--of dopaminergic system.