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Intestinal lymphoma associated with malabsorption

P Isaacson, D H Wright

    Lancet (London, England)
    |January 14, 1978
    PubMed
    Summary
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    This study examines small-intestinal lymphoma in patients with malabsorption. Researchers found malignant histiocytes in these lymphomas, suggesting a specific entity linked to malabsorption syndromes.

    Area of Science:

    • Gastroenterology
    • Oncology
    • Immunology

    Background:

    • Small-intestinal lymphoma can present with symptoms mimicking malabsorption syndromes like adult celiac disease.
    • Villous atrophy and crypt hyperplasia in the small intestine are associated with certain lymphomas.

    Purpose of the Study:

    • To characterize lymphomas in patients with villous atrophy and crypt hyperplasia.
    • To investigate the relationship between malabsorption and small-intestinal lymphoma.
    • To explore the immunological profile of these malignant cells.

    Main Methods:

    • Morphological classification of lymphomas.
    • Immunohistochemical techniques to identify immunoglobulin expression in tumor cells.
    • Clinical data review of 18 patients presenting with abdominal pain, weight loss, obstruction, or perforation.

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    Main Results:

    • Most patients (18) presented with acute obstruction or perforation following abdominal pain and weight loss.
    • Malabsorption, initially diagnosed as adult celiac disease, preceded lymphoma diagnosis in 5 cases.
    • Lymphomas were composed of malignant histiocytes, classified as malignant histiocytosis.
    • Immunohistochemistry revealed all major immunoglobulin classes within malignant cells of individual tumors.

    Conclusions:

    • The characterized lymphomas, composed of malignant histiocytes, may represent a specific entity.
    • Understanding this lymphoma subtype can clarify the link between malabsorption and intestinal lymphoma.
    • Further research may aid in rationalizing treatment strategies for this condition.