[Eosinophilic fasciitis. A recently reported oligotopic connective tissue inflammation. A case report]

A 25 year old suffering from eosinophilic fasciitis is reported. This patient showed periostitis at some bones and myatrophy of thenar and hypothenar besides the typical manifestations related to the involvement of fascia and nearby tissues. On the whole these manifestations reduced the patient's mobility seriously. The typical humoral findings of eosinophilic fasciitis were present, i. e. remarkable eosinophilia, hypergammaglobulinemia with rise of Ig G, and inflammatory serum alterations. Furthermore an increase urinary hydroxyproline excretion was found which means an altered collagen metabolism. This is obviously related to collagen accumulation that in this patient was observed at fascia, perimysium and in the subcutaneous tissue. Ig G deposits were found in the fascia. The reported case raised some problems of differential diagnosis with polymyositis, progressive systemic sclerosis, localized scleroderma and, perhaps, mixed connective tissue disease.