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Hypoparathyroidism in diabetes mellitus
Acta Endocrinologica
|January 1, 1981
Summary
Insulin-treated diabetic patients often exhibit low serum parathyroid hormone (iPTH) levels, linked to poor glucose control and longer disease duration. This suggests diabetic hypoparathyroidism may stem from bone metabolism disturbances.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Bone Metabolism
Background:
- Diabetes mellitus is associated with various metabolic complications.
- Parathyroid hormone (PTH) plays a crucial role in mineral homeostasis.
- The impact of diabetes on PTH levels and bone metabolism requires further investigation.
Purpose of the Study:
- To investigate serum immunoreactive parathyroid hormone (iPTH) levels in insulin-treated diabetic patients.
- To assess the relationship between iPTH levels, mineral metabolism, and glucose control.
- To explore potential links between diabetes duration, iPTH, and bone mass.
Main Methods:
- Serum iPTH, magnesium, calcium, and glucose metabolism indices were measured in 58 insulin-treated diabetic patients.
- Patients were categorized based on glycosuria and diabetes duration.
- Comparisons were made with normal subjects.
Main Results:
- Diabetic patients showed significantly lower mean serum iPTH levels (55% of normal, P < 0.01).
- Hypomagnesaemia, hypercalciuria, and reduced bone mass (9.6%) were observed in diabetic patients.
- Low iPTH correlated with high glycosuria (R = -0.28) and longer diabetes duration (R = -0.31).
Conclusions:
- Diabetic patients exhibit reduced serum iPTH, hypomagnesaemia, and hypercalciuria, indicating potential diabetic hypoparathyroidism.
- Low iPTH levels are associated with poorer glycemic control and extended diabetes duration.
- Diabetic hypoparathyroidism may be secondary to bone metabolism disturbances and negative calcium balance.