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Intestinal absorption in the aged

L Pénzes

    Acta Medica Academiae Scientiarum Hungaricae
    |January 1, 1980
    PubMed
    Summary

    Aging reduces intestinal carrier affinity for d-glucose and amino acid absorption in rats. This impacts nutrient transport, with faster absorption in young animals for most molecules but not basic amino acids.

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    Area of Science:

    • Gastroenterology
    • Gerontology
    • Molecular Biology

    Background:

    • Differentiating functional gastrointestinal disorders from organic diseases in the elderly is challenging.
    • Age-related structural changes in the digestive tract do not definitively indicate functional disorders.
    • The impact of aging on nutrient absorption, specifically d-glucose and amino acids, remains unclear.

    Purpose of the Study:

    • To investigate whether aging affects the intestinal absorption of d-glucose and specific amino acids.
    • To elucidate the kinetic changes in nutrient transport associated with aging in the gastrointestinal tract.

    Main Methods:

    • Utilized a kinetic approach in rat experiments to study nutrient absorption.
    • Quantified the transport rates of d-glucose and a panel of amino acids (glycine, alanine, valine, threonine, leucine, phenylalanine, tryptophan, proline, histidine, lysine, arginine).

    Main Results:

    • Intestinal carrier affinity for transported molecules significantly declines with aging.
    • Young rats exhibit higher transport rates for most absorbed molecules at low concentrations compared to aged rats.
    • A reversed trend was observed for basic amino acids, with higher transport rates in aged rats.

    Conclusions:

    • Aging alters the kinetics of intestinal nutrient absorption.
    • Reduced carrier affinity in aged rats impacts the efficiency of d-glucose and amino acid uptake.
    • Specific amino acid transport mechanisms, particularly for basic amino acids, may be preserved or enhanced with age.

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