[Experimental artificial embolization in animals: consequences and clinical applications (author's transl)]

Area of Science:

• Vascular surgery
• Interventional radiology
• Biomedical engineering

Background:

• Arteriovenous fistulas are abnormal connections between arteries and veins.
• Embolization is a minimally invasive procedure to block blood flow.
• Understanding emboli migration is crucial for interventional procedures.

Purpose of the Study:

• To investigate the migration patterns of different embolization materials.
• To assess the transport of emboli from the systemic to the central circulation.
• To evaluate the efficacy of embolization materials in a controlled fistula model.

Main Methods:

• Creation of an arteriovenous fistula between the jugular vein and common carotid artery in rabbits.
• Demonstration of the fistula using angiography.
• Embolization using iodine-131 labeled fibrin, Tabotamp, and Lyo-Dura.
• Scintigraphic monitoring of emboli migration with an Anger camera.

Main Results:

• Successful creation and demonstration of the arteriovenous fistula.
• Iodine-131 labeled embolization materials were visualized using scintigraphy.
• Demonstrated transport of embolization materials from the peripheral (small) circulation to the central (great) circulation.

Conclusions:

• Embolization materials can migrate from the site of administration to the central circulation.
• The study provides insights into the behavior of embolization agents in a vascular fistula model.
• Further research is warranted to optimize embolization techniques and material selection.