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Mucin-like changes in keloids

D J Santa Cruz, T M Ulbright

    American Journal of Clinical Pathology
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Earlobe keloids can develop unusual mucinous material after corticosteroid injections. This distinct histopathologic finding, different from typical mucinoses, aids in diagnosis.

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    Area of Science:

    • Dermatopathology
    • Histopathology
    • Cutaneous Medicine

    Background:

    • Keloids are common benign skin growths, particularly on earlobes.
    • Corticosteroid injections are a frequent treatment for keloids.
    • Unusual histopathologic findings can complicate diagnosis.

    Purpose of the Study:

    • To describe a peculiar mucinous material found in earlobe keloids.
    • To differentiate this finding from other cutaneous mucinoses.
    • To correlate the histopathologic features with corticosteroid treatment history.

    Main Methods:

    • Histopathologic examination of six earlobe keloid specimens.
    • Histochemical analysis of the stromal material.
    • Clinical history review focusing on prior corticosteroid injections.

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    Main Results:

    • Six of 125 earlobe keloids showed stromal accumulation of amorphous eosinophilic material.
    • Histochemical studies indicated the material is distinct from hyaluronic acid-rich mucins.
    • The material was surrounded by a granulomatous response with giant cells and histiocytes.

    Conclusions:

    • This specific mucinous change in earlobe keloids is associated with prior corticosteroid injections.
    • The lesion is histopathologically distinct from usual cutaneous mucinoses.
    • Recognition of this entity is crucial to avoid misdiagnosis.