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Catecholamines in human amniotic fluid

M Phillippe, K J Ryan

    American Journal of Obstetrics and Gynecology
    |January 15, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Amniotic fluid catecholamine levels, including norepinephrine, epinephrine, and dopamine, significantly increase in the third trimester. This rise may stimulate prostaglandin synthesis as childbirth approaches.

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    Area of Science:

    • Reproductive Endocrinology
    • Maternal-Fetal Medicine
    • Neuroendocrinology

    Background:

    • Catecholamines (epinephrine, norepinephrine, dopamine) are crucial signaling molecules.
    • Their presence and role in human amniotic fluid, particularly in late gestation, require further elucidation.

    Purpose of the Study:

    • To quantify amniotic fluid levels of epinephrine (E), norepinephrine (N), and dopamine (D).
    • To investigate the relationship between these catecholamine levels and gestational age in humans.

    Main Methods:

    • Amniotic fluid samples were collected from 32 pregnant women via amniocentesis (17-39 weeks gestation).
    • Radioenzyme assay was employed to measure catecholamine concentrations.
    • Patients were not in active labor at the time of sample collection.

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    Main Results:

    • A significant increase in norepinephrine, epinephrine, and dopamine levels was observed at the end of the third trimester.
    • Specifically, dopamine showed a marked rise (2717.0 +/- 836.6 pg/ml, p < 0.01).
    • Norepinephrine (362.7 +/- 61.2 pg/ml) and epinephrine (179.6 +/- 45.4 pg/ml, p < 0.05) also increased.

    Conclusions:

    • Human amniotic fluid catecholamine levels, especially dopamine, rise substantially in late pregnancy.
    • These elevated catecholamines may play a role in stimulating intrauterine prostaglandin synthesis.
    • This suggests a potential mechanism influencing the onset of parturition.