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Renal nerves and catecholamine excretion

N Morgunov, A D Baines

    The American Journal of Physiology
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Renal nerves release both dopamine (DA) and norepinephrine (NE). Their excretion, influenced by diet, impacts sodium excretion, revealing a complex interplay in kidney function.

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    Area of Science:

    • Nephrology
    • Neuroendocrinology
    • Renal Physiology

    Background:

    • The role of neurotransmitters released by renal nerves in regulating kidney function is not fully understood.
    • Norepinephrine (NE) and dopamine (DA) are key neurotransmitters found in renal nerves, but their specific urinary excretion patterns and functional significance require elucidation.

    Purpose of the Study:

    • To identify neurotransmitters released by renal nerves into urine.
    • To investigate the impact of renal nerve activity and dietary sodium on neurotransmitter and sodium excretion.
    • To elucidate the relationship between dopamine, norepinephrine, and sodium excretion.

    Main Methods:

    • Acute and chronic unilateral renal denervation in animal models.
    • Baroreflex activation to stimulate renal nerves.

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  • Measurement of urinary dopamine (DA) and norepinephrine (NE) excretion.
  • Assessment of sodium excretion in response to denervation and baroreflex stimulation.
  • Dietary manipulation with low and high salt diets.

    • Main Results:

    • Acute denervation altered DA and NE excretion, with DA increasing and NE decreasing in the denervated kidney, while the contralateral kidney showed opposite changes.
    • Sodium excretion correlated directly with DA and inversely with NE excretion after acute denervation.
    • Baroreflex stimulation increased NE and DA excretion from innervated kidneys, an effect modulated by dietary sodium intake, being reduced by low salt and abolished by high salt diets.

    Conclusions:

    • Renal nerves demonstrably release both norepinephrine (NE) and dopamine (DA) into the urinary system.
    • The interplay between DA and NE excretion, modulated by renal nerve activity, directly influences sodium excretion.
    • Dietary sodium intake significantly impacts the urinary excretion of NE and DA originating from renal nerves.