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Prostaglandins in human milk

A Lucas, M D Mitchell

    Archives of Disease in Childhood
    |December 1, 1980
    PubMed
    Summary

    Breast milk contains high levels of Prostaglandins E and F, with a longer half-life than in adult plasma. These milk prostaglandins may influence neonatal physiology, such as gut motility.

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    Area of Science:

    • Biochemistry
    • Neonatal Physiology

    Background:

    • Prostaglandins E and F are present in breast milk at significantly higher concentrations than in adult plasma.
    • The ratio of prostaglandin F metabolite to prostaglandin F in milk suggests a prolonged half-life in this medium.

    Purpose of the Study:

    • To investigate the presence and potential role of prostaglandins in breast milk.
    • To compare prostaglandin concentrations and metabolism in breast milk versus adult plasma.

    Main Methods:

    • Quantification of Prostaglandins E and F in breast milk.
    • Measurement of prostaglandin F metabolite concentrations in breast milk.
    • Comparison with adult plasma prostaglandin levels.

    Main Results:

    • Breast milk exhibited over 100-fold higher concentrations of Prostaglandins E and F compared to adult plasma.
    • A low ratio of 13,14-dihydro-15-ketoprostaglandin F to prostaglandin F (0.3-0.5) was observed in milk, versus 15.8 in plasma.
    • Significant amounts of inactive thromboxane A2 and prostacyclin metabolites were also detected in breast milk.

    Conclusions:

    • Prostaglandins are highly concentrated in breast milk and possess a longer half-life, suggesting stability within this environment.
    • Milk prostaglandins may play a crucial role in regulating neonatal physiological functions, including gut motility.

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