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Neurofibrillary change on Guam

L Chen

    Archives of Neurology
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Neurofibrillary changes (NFC) were found in most older Guamanians, suggesting a widespread exposure to an unknown cause of amyotrophic lateral sclerosis-parkinsonism dementia (ALS-PD). This indicates a potential environmental link to the disease in the general population.

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    Area of Science:

    • Neurology
    • Neuroscience
    • Environmental Health

    Background:

    • Amyotrophic lateral sclerosis-parkinsonism dementia (ALS-PD) is a neurodegenerative disease prevalent in Guam.
    • The etiology of ALS-PD remains unknown, prompting investigations into environmental factors.

    Purpose of the Study:

    • To investigate the distribution and occurrence of neurofibrillary change (NFC) in the brain of Guamanians without ALS-PD.
    • To compare NFC presence in Guamanians with and without ALS-PD, and in non-Guamanians.
    • To explore potential environmental exposures in the Guamanian population.

    Main Methods:

    • Examined brain tissue for neurofibrillary changes (NFC) in 114 Guamanians without ALS-PD.
    • Compared findings with 28 Guamanians diagnosed with ALS-PD and 53 non-Guamanians without the disease.

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  • Investigated NFC in 15 domestic animals (dogs and cats) from Guam.

    • Main Results:

    • Most Guamanians without ALS-PD, particularly those middle-aged and older, exhibited NFC.
    • The degree and extent of NFC in the general Guamanian population were less severe than in ALS-PD patients.
    • NFC was also observed in domestic animals on Guam.

    Conclusions:

    • The widespread presence of NFC in the Guamanian population suggests a common exposure to an unknown etiologic agent.
    • This finding supports the hypothesis of an environmental factor contributing to ALS-PD in Guam.
    • Further research is needed to identify the specific environmental agent responsible for ALS-PD.