Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serial changes in renal haemodynamics during normal human pregnancy

W Dunlop

    British Journal of Obstetrics and Gynaecology
    |January 1, 1981
    PubMed
    Summary

    During pregnancy, effective renal plasma flow (ERPF) initially rises then falls, while glomerular filtration rate (GFR) remains elevated. These changes impact kidney function and filtration fraction throughout gestation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A Model to Estimate the Health System Burden of Prescription Opioid Abuse in Europe.

    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2016
    Same author

    Budget Impact Analysis of Introducing Biosimilar Infliximab for the Treatment of Auto Immune Disorders In Five European Countries.

    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2016
    Same author

    Endpoints in Pain: the Suitability for Health Economic Evaluation of Endpoint Designs in Chronic Pain Studies.

    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2016
    Same author

    A Systematic Search and Methodological Review of Economic Models of Analgesics for Chronic Pain.

    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2016
    Same author

    Device Handling Errors and the Impact on Quality of Life and Health Care Resource Use in Asthmatic Patients.

    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2016
    Same author

    The Socioeconomic Costs of the Undertreatment of Pain.

    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2016

    Area of Science:

    • Nephrology
    • Obstetrics
    • Physiology

    Background:

    • Pregnancy significantly alters maternal physiology.
    • Understanding renal hemodynamics during pregnancy is crucial for maternal and fetal health.

    Purpose of the Study:

    • To investigate changes in effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) during normal pregnancy.
    • To analyze the dynamic alterations in renal function throughout gestation.

    Main Methods:

    • Longitudinal study involving 25 healthy pregnant women.
    • Regular determination of ERPF and GFR at intervals during and after pregnancy.
    • Calculation of filtration fraction (GFR/ERPF).

    Main Results:

    • ERPF increased by 80% in early pregnancy but decreased in the third trimester.
    • GFR remained approximately 50% above non-pregnant levels throughout pregnancy.
    • Filtration fraction was reduced in early pregnancy and normalized by the third trimester.

    Conclusions:

    • Pregnancy induces distinct temporal changes in renal hemodynamics.
    • Sustained elevation of GFR with fluctuating ERPF characterizes pregnancy-related renal adaptation.
    • Re-interpretation of existing data supports these findings.

    Related Experiment Videos