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Keratoconus: maternal age and social class

E G Woodward

    The British Journal of Ophthalmology
    |February 1, 1981
    PubMed
    Summary

    Patients with keratoconus often have older mothers compared to the general population. This study suggests a link between advanced maternal age and keratoconus, potentially influenced by social class factors.

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    Area of Science:

    • Ophthalmology
    • Genetics
    • Sociology

    Background:

    • Keratoconus is a progressive eye condition affecting corneal shape.
    • Etiology of keratoconus remains multifactorial, with potential genetic and environmental influences.

    Purpose of the Study:

    • To investigate the association between maternal age at birth and the occurrence of keratoconus in offspring.
    • To explore the role of social class in the context of maternal age and keratoconus.

    Main Methods:

    • A cohort of 150 patients diagnosed with keratoconus was surveyed.
    • Data collected included the patients' maternal age at the time of their birth.
    • Social class distribution of the patient group was compared to the general population.

    Main Results:

    • A statistically significant higher prevalence of older mothers was observed in the keratoconus patient group compared to general population data.
    • The social class distribution among keratoconus patients differed significantly from the general population.
    • A correlation between advanced maternal age and social class in keratoconus patients was suggested.

    Conclusions:

    • Advanced maternal age may be a risk factor for developing keratoconus.
    • Social class may play a mediating role in the relationship between maternal age and keratoconus.
    • Further research is warranted to elucidate the complex interplay of genetics, environment, and socioeconomic factors in keratoconus pathogenesis.

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