Related Experiment Video
Updated: Sep 12, 2026

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
[Role of the mastocytes during functional activation of the thyroid]
Abstract:
The behaviour of biogenic amines in mastocytes has been studied in the thyroid glands of rats treated with 2 U.I. of TSH. The histochemical evaluation of histamine and 5-HT in mastocytes with the method of fluorochromization has been carried out at 20 minutes and 120 minutes after TSH administration. After 20 minutes, the thyroid glands do not present evident parenchymal changes, but the positivity for biogenic amines in mastocytes decreases in comparison to the controls, while this positivity begins to be evident in the interstitial tissue. After 120 minutes, the thyroid gland shows a microfollicular arrangement and the fluorescent biogenic amines appear to be released in the interstitium by degranulating mastocytes, nearly entirely negative to fluorochromization.
Related Concept Videos
The Thyroid Gland
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Functions of Thyroid Hormones
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
Hyperthyroidism I: Introduction
Hyperthyroidism II: Pathophysiology
Graves Disease II: Pathophysiology

