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Retroperitoneal fibrosis: practical problems in management

G F Abercrombie, J Vinnicombe

British Journal of Urology

|December 1, 1980

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Retroperitoneal fibrosis, often idiopathic, can extend post-surgery. Low-dose steroids may help manage elevated sedimentation rates and prevent late disease manifestations in these patients.

Area of Science:

Nephrology
Urology
Pathology

Background:

Retroperitoneal fibrosis (RPF) is a rare condition characterized by inflammation and fibrous tissue in the retroperitoneum.
Idiopathic RPF accounts for the majority of cases, though secondary causes like methysergide use exist.

Purpose of the Study:

To review outcomes of patients with retroperitoneal fibrosis undergoing surgical intervention.
To evaluate the efficacy of low-dose steroids in managing post-operative complications and late manifestations.

Main Methods:

Retrospective review of 19 patients diagnosed with retroperitoneal fibrosis.
Analysis of surgical interventions, specifically primary bilateral ureterolysis in 13 patients.
Assessment of post-operative complications and disease progression.

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Main Results:

Eighteen patients had idiopathic retroperitoneal fibrosis; one had methysergide-induced disease.
Five patients experienced disease extension following primary bilateral ureterolysis.
Elevated sedimentation rates were observed in patients with post-operative disease progression.

Conclusions:

Surgical intervention for retroperitoneal fibrosis carries a risk of disease extension.
Low-dose steroid therapy may be beneficial for patients with elevated sedimentation rates post-surgery.
Steroids could potentially prevent late-onset complications associated with retroperitoneal fibrosis.