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Related Experiment Videos

Coagulation changes after albumin resuscitation

T H Cogbill, E E Moore, E L Dunn

    Critical Care Medicine
    |January 1, 1981
    PubMed
    Summary
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    Albumin resuscitation in shock did not impair hemostasis. This study found albumin therapy did not significantly affect platelet count, function, or fibrinogen levels after hemorrhagic shock.

    Area of Science:

    • Critical Care Medicine
    • Hematology
    • Surgical Research

    Background:

    • Albumin administration during shock resuscitation is controversial.
    • Concerns exist regarding albumin's potential to impair coagulation in critically injured patients.

    Purpose of the Study:

    • To investigate the hemostatic effects of albumin therapy following hemorrhagic shock.
    • To determine if albumin impacts key coagulation parameters.

    Main Methods:

    • Hemorrhagic shock was induced in 20 mongrel dogs.
    • Animals received either lactated Ringer's solution or 5% serum albumin (25 ml/kg) for 3 days post-resuscitation.
    • Coagulation parameters (platelet count, function, fibrinogen, PT, PTT) were measured serially.

    Main Results:

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    • Albumin therapy did not significantly alter platelet count, platelet function, or serum fibrinogen levels compared to controls.
    • Prothrombin time and partial thromboplastin time were prolonged in the albumin group but did not cause clinical bleeding.

    Conclusions:

    • Albumin therapy in the context of hemorrhagic shock resuscitation did not demonstrate clinically significant impairment of hemostasis.
    • Further investigation into albumin's role in critical care is warranted.