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The Nikolsky sign

M Polifka, P A Krusinski

    Cutis
    |November 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    The Nikolsky sign, used for diagnosing pemphigus, shows varied definitions and applications across many skin conditions. Further research is needed to clarify its diagnostic utility and standardize its interpretation in dermatology.

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    Area of Science:

    • Dermatology
    • Clinical diagnostics

    Background:

    • The Nikolsky sign is a well-established physical examination finding.
    • It is traditionally associated with the clinical diagnosis of pemphigus vulgaris and related autoimmune blistering diseases.

    Purpose of the Study:

    • To review the literature on the Nikolsky sign.
    • To assess its origin, application, and clinical usefulness in diagnosing dermatologic conditions.
    • To identify variations in its definition and diagnostic criteria.

    Main Methods:

    • Comprehensive literature review of studies mentioning the Nikolsky sign.
    • Analysis of reported associations between the sign and various dermatologic diseases.
    • Evaluation of the consistency in defining a positive Nikolsky sign.

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    Main Results:

    • The Nikolsky sign is associated with a broader range of dermatologic conditions than previously recognized.
    • Significant disparities exist in the literature regarding the precise definition of a positive Nikolsky sign.
    • Limited documentation supports the wide variations in its application and interpretation.

    Conclusions:

    • The clinical utility of the Nikolsky sign may be limited by inconsistent definitions and applications.
    • Standardization of the Nikolsky sign's definition and diagnostic criteria is warranted.
    • Further investigation is needed to clarify its role in the diagnosis of pemphigus and other skin diseases.