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Identification of dihydrofolate reductase in human central-nervous-system tumours
Lancet (London, England)
|January 28, 1978
Abstract:
Ten primary and two metastatic central-nervous system (C.N.S.) tumours were assayed. They all contained dihydrofolate reductase. This finding provides a biochemical rationale for antifolate therapy of C.N.S. tumours by methotrexate.
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