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81mKr gas generator for lung ventilation study

T Koyama, T Koyama, Y Hirokawa

European Journal of Nuclear Medicine

|December 1, 1980

Summary

A novel generator for Krypton-81m (81mKr) was developed for lung ventilation studies. It efficiently produces and collects 81mKr from its parent 81Rubidium (81Rb) using proton-induced reactions.

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Area of Science:

Nuclear medicine
Radiochemistry
Medical physics

Background:

Krypton-81m (81mKr) is a valuable radionuclide for lung ventilation imaging.
Efficient and reliable methods for 81mKr production are crucial for clinical applications.

Purpose of the Study:

To design, construct, and evaluate a generator system for producing and collecting 81mKr.
To assess the performance of the generator at high flow rates for potential clinical use.

Main Methods:

The parent nuclide, Rubidium-81 (81Rb), was synthesized via 70 MeV proton-induced reactions on a Rubidium sulfate (Rb2SO4) target.
81mKr was separated from the 81Rb solution by bubbling with oxygen gas.
The 81mKr was collected in a reservoir and its purity was confirmed using a NaI(Tl) detector.

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Main Results:

The generator was successfully designed and tested, demonstrating continuous operation at flow rates up to 10 L/min.
An overall generator efficiency of 86% was achieved.
The collection rates of 81mKr in the reservoir were characterized under various flow conditions, and the purity of the 81mKr isomer was confirmed.

Conclusions:

The developed generator system provides an efficient method for producing and collecting 81mKr for lung ventilation studies.
The generator's ability to operate at high flow rates and its high efficiency make it suitable for clinical applications.