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Related Concept Videos

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

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Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows...
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Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

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Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

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Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The...
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Murine Ileocolic Bowel Resection with Primary Anastomosis
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Malignancy in Crohn's disease

S N Gyde, P Prior, J C Macartney

    Gut
    |December 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Patients with Crohn's disease (CD) have an elevated risk of developing cancer, particularly within the digestive system. This study found a 1.7-fold increased overall cancer risk and a 3.3-fold increased risk for digestive system tumors in CD patients.

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    Area of Science:

    • Gastroenterology
    • Oncology
    • Epidemiology

    Background:

    • Crohn's disease (CD) is a chronic inflammatory bowel disease.
    • Long-term inflammatory conditions may increase cancer risk.
    • Previous studies suggest a potential link between CD and cancer.

    Purpose of the Study:

    • To evaluate cancer morbidity in a cohort of patients with Crohn's disease.
    • To compare cancer incidence in CD patients with the general population.
    • To identify specific sites of increased cancer risk associated with CD.

    Main Methods:

    • Retrospective analysis of 513 patients with Crohn's disease.
    • Long-term follow-up data collection from 1944-1976.
    • Comparison of observed cancer cases against regional cancer morbidity rates.

    Main Results:

    • A total of 31 tumors were diagnosed in the patient cohort.
    • Overall cancer risk was significantly elevated (relative risk = 1.7, P < 0.01).
    • Digestive system cancer risk was substantially higher (relative risk = 3.3, P < 0.001), affecting both upper and lower GI tracts.

    Conclusions:

    • Patients with Crohn's disease face a significantly increased risk of developing cancer.
    • The elevated cancer risk is primarily concentrated within the digestive system.
    • Further research is warranted to understand the mechanisms driving this association.