gamma-Carboxyglutamic acid-containing protein of rat kidney cortex. Changes with high fat diet, and molecular...

It was shown that the level of gamma-carboxyglutamic acid-containing protein is increased in perfused rat kidney after long-term administration (60 and 350 days) of a high-fat diet. No difference was found between the effect of vegetable fat and animal fat. Concomitantly it was shown that the relative molecular weight, N-terminal sequence over four residues, the profile of chymotryptic peptides and the sequence around the two (of the three in total) gamma-carboxyglutamic acid residues (over the span of seven residues) are identical with those found previously in osteocalcin and the gamma-carboxyglutamic acid-containing protein isolated from at least partially calcified connective tissue.