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Related Concept Videos

Phase Diagrams02:39

Phase Diagrams

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A phase diagram combines plots of pressure versus temperature for the liquid-gas, solid-liquid, and solid-gas phase-transition equilibria of a substance. These diagrams indicate the physical states that exist under specific conditions of pressure and temperature and also provide the pressure dependence of the phase-transition temperatures (melting points, sublimation points, boiling points). Regions or areas labeled solid, liquid, and gas represent single phases, while lines or curves represent...
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Metallic Solids02:37

Metallic Solids

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Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
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Structures of Solids02:22

Structures of Solids

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Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
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Phase Transitions02:31

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Whether solid, liquid, or gas, a substance's state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the solid pack closely together, generally in a pattern. The particles vibrate about their fixed positions but do not move or squeeze past their neighbors. In liquids, although the particles are closely spaced, they are randomly arranged. The position of the particles are not fixed—that is, they are free to move past their neighbors to...
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Network Covalent Solids02:18

Network Covalent Solids

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Phase Transitions: Sublimation and Deposition

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Related Experiment Video

Updated: Feb 14, 2026

An Inexpensive Adaptation of a Commercial Microwave Reactor for Solid Phase Peptide Synthesis
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An Inexpensive Adaptation of a Commercial Microwave Reactor for Solid Phase Peptide Synthesis

Published on: November 22, 2024

843

Solid-phase synthesis of human pancreatic polypeptide

C A Meyers, D H Coy

    International Journal of Peptide and Protein Research
    |October 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Synthetic human pancreatic polypeptide (HPP) was created and purified using advanced techniques. The synthesized HPP effectively inhibited pancreatic secretion in dogs, matching native pancreatic polypeptide activity.

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    Area of Science:

    • Biochemistry
    • Endocrinology
    • Peptide Chemistry

    Background:

    • Human pancreatic polypeptide (HPP) is a peptide hormone involved in regulating various physiological processes.
    • Understanding the structure-activity relationship of HPP is crucial for its therapeutic applications.

    Purpose of the Study:

    • To synthesize human pancreatic polypeptide (HPP) using solid-phase methodology.
    • To characterize the synthetic HPP and compare it with native pancreatic polypeptide from different species.
    • To evaluate the biological activity of synthetic HPP as an inhibitor of pancreatic secretion.

    Main Methods:

    • Solid-phase peptide synthesis for HPP production.
    • High-performance liquid chromatography (HPLC) for purification and characterization.
    • Cyanogen bromide cleavage for fragment analysis.
    • In vivo studies in dogs to assess pancreatic secretion inhibition.

    Main Results:

    • Successfully synthesized and purified 36-residue HPP with high homogeneity confirmed by RP-HPLC.
    • Characterized cyanogen bromide cleavage fragments of synthetic HPP.
    • Demonstrated that synthetic HPP effectively inhibits pancreatic secretion in dogs, similar to native pancreatic polypeptide.
    • Compared synthetic HPP with native human, bovine, and porcine pancreatic polypeptide.

    Conclusions:

    • Solid-phase synthesis is a viable method for producing biologically active human pancreatic polypeptide.
    • Synthetic HPP exhibits potent inhibitory effects on pancreatic secretion, comparable to native forms.
    • This study provides a reliable source of HPP for further physiological and pharmacological investigations.