Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vasculitis in chronic urticaria: an immunopathologic study

E W Monroe, C I Schulz, J C Maize

    The Journal of Investigative Dermatology
    |February 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Desloratidine for the treatment of chronic urticaria.

    Skin therapy letter·2003
    Same author

    Cryofibrinogenemia in a patient with B-cell lymphoma.

    Clinical lymphoma·2001
    Same author

    Interphase cytogenetic analysis of 1q12 satellite III DNA in melanocytic lesions: increased aneuploidy with malignant histology.

    The American Journal of dermatopathology·2001
    Same author

    A phase III, randomized, double-blind, placebo-controlled study of peldesine (BCX-34) cream as topical therapy for cutaneous T-cell lymphoma.

    Journal of the American Academy of Dermatology·2001
    Same author

    Melanoma thickness and histology predict sentinel lymph node status.

    American journal of surgery·2001
    Same author

    A combination benzoyl peroxide and clindamycin topical gel compared with benzoyl peroxide, clindamycin phosphate, and vehicle in the treatment of acne vulgaris.

    Cutis·2001
    Same journal

    Residual CSB activity explains mild UV-sensitive syndrome phenotype caused by CSB mutations.

    The Journal of investigative dermatology·2026
    Same journal

    Charting a new melanoma risk factor: Satellite Naevus Prevalence in High-Risk and Population-Based Cohorts.

    The Journal of investigative dermatology·2026
    Same journal

    Human keratinocytes and fibroblasts coordinate early cutaneous innate defenses against Candida auris.

    The Journal of investigative dermatology·2026
    Same journal

    Merkel cells attenuate autoantigen-specific T cell driven skin inflammation in mice associated with reduced neutrophil recruitment.

    The Journal of investigative dermatology·2026
    Same journal

    The response of human melanocytic nevi to simulated solar radiation assessed by single-nucleus RNA sequencing of frozen tissue.

    The Journal of investigative dermatology·2026
    Same journal

    Impact of Online vs In-Person Management of Atopic Dermatitis on Quality of Life and Access to Care: A Randomized Controlled Trial.

    The Journal of investigative dermatology·2026
    See all related articles

    A study of chronic urticaria patients found that a significant number exhibit leukocytoclastic vasculitis, characterized by immune complex deposition. This suggests vasculitis is an important factor in chronic hives.

    Area of Science:

    • Dermatology
    • Immunology
    • Pathology

    Background:

    • Chronic urticaria is a common dermatological condition.
    • Its underlying pathophysiology is not fully understood.
    • Histologic findings can vary among patients.

    Purpose of the Study:

    • To determine the incidence of leukocytoclastic vasculitis in chronic urticaria.
    • To identify clinical, laboratory, and immunopathologic parameters associated with vasculitis in these patients.

    Main Methods:

    • Histopathologic examination of skin biopsies from 45 chronic urticaria patients.
    • Assessment of circulating immune complexes using Clq binding and rheumatoid factor inhibition assays.
    • Direct immunofluorescence to detect immunoglobulin and complement deposition in blood vessels.

    Related Experiment Videos

    Main Results:

    • Leukocytoclastic vasculitis was identified in 9 patients.
    • A dense perivascular infiltrate was seen in 15 patients, and a sparse infiltrate in 21.
    • Increased circulating immune complexes were found in vasculitis and dense infiltrate groups.
    • Immunoglobulin, complement, or fibrin deposition occurred in 33% of the vasculitis group.

    Conclusions:

    • A notable proportion of chronic urticaria patients present with histologic and immunopathologic evidence of vasculitis.
    • These findings highlight the role of vasculitis in the pathogenesis of chronic urticaria.