Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intrarenal insoluble immune complex formation

W F Clark, D I Turnbull, A A Driedger

    Journal of Clinical & Laboratory Immunology
    |July 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    ECG machine QTc intervals are inaccurate in hemodialysis patients.

    Nephron. Clinical practice·2013
    Same author

    Ventilation studies performed after the perfusion lung scan.

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2013
    Same author

    The neurotrophin family of NGF-related neurotrophic factors.

    Restorative neurology and neuroscience·2011
    Same author

    Acute renal failure.

    Canadian Medical Association journal·2010
    Same author

    Physicians rally against threat of a nuclear epidemic.

    Canadian Medical Association journal·2010
    Same author

    Technical aspects of home hemodialysis.

    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia·2009

    In swine, insoluble immune complex formation causes kidney damage, affecting platelets and basophils. This model mimics human progressive glomerulonephritis, showing scarring and reduced kidney function.

    Area of Science:

    • Nephrology
    • Immunology
    • Pathology

    Background:

    • Intrarenal insoluble immune complex formation causes mesangiopathic lesions and focal glomerulosclerosis in rabbits.
    • Swine platelets are more immunologically similar to human platelets than rabbit platelets.

    Purpose of the Study:

    • To investigate the relationship between insoluble immune complex formation, glomerular deposition, and renal vein changes in swine.
    • To characterize the scarring pattern and functional impairment resulting from this immune reaction.

    Main Methods:

    • Swine were challenged with direct renal antigen twice weekly during persistent antibody excess.
    • Renal biopsies were performed 20 minutes post-challenge to assess immune complex deposition.
    • Renal vein platelet and basophil counts were monitored.

    Related Experiment Videos

  • Glomerular filtration was assessed one week after the second antigen challenge.

    • Main Results:

    • Immune complex glomerular deposition was observed shortly after antigen challenge.
    • A significant decrease in renal vein platelet and basophil counts occurred during immune complex formation.
    • A weak association was found between basophil count and white blood cell count changes.
    • A scarring mesangiopathic lesion with persistent reduction in glomerular filtration was noted.

    Conclusions:

    • Insoluble immune complex formation in swine leads to glomerular deposition, platelet/basophil changes, and renal scarring.
    • This swine model replicates key features of human progressive mesangiopathic glomerulonephritis.
    • Platelet-mediated permeability factors may facilitate glomerular immune complex deposition in this model.